University of Connecticut

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Neuroscience Seminar Series - Shahnawaz

Thursday, September 23, 2021
11:00am – 12:00pm

UConn Health

Sponsored by the Kim Family Fund

"Discriminating Alpha-synuclein strains and sub-strains in Synucleinopathies"

Presenter: Mohammad Shahnawaz, Ph.D. Assistant Professor, Department of Neurology Mitchell Center for Alzheimer’s Disease and Related Brain Disorders Houston, TX

BACKGROUND: Synucleinopathies are a diverse group of neurodegenerative diseases characterized by misfolding aggregation and accumulation of misfolded alpha-synuclein (αSyn) in neurons or glial cells, which include Parkinson’s disease (PD) multiple system atrophy (MSA), and dementia with Lewy bodies (DLB). Although they share the same pathological protein, different synucleinopathies present distinct clinical and pathological phenotypes. Clinically, it is very challenging to differentiate particularly PD from MSA, especially at the early stage of the disease. Accumulating evidence suggests that αSyn aggregates associated with different synucleinopathies adopt distinct conformational strains. Our results also suggest the existence of distinct αSyn strains with the same disease (here called sub-strains to avoid confusion). αSyn strains and sub-strains faithfully self-propagate and spread between cells. We propose that discrimination of these conformational αSyn strains and sub-strains hold promise for differential diagnosis and understanding the relationship between structures of αSyn strains and sub-strains and their pathologic functions.

Host: Dr. Md Golam Sharaor,


Jody Gridley,

Neuroscience Department at UConn Health (primary), UConn Health Master Calendar

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